Research groups


Discovery, improvement and rational exploitation of high performance enzymatic biocatalysts. Integrated use of microbiology, metagenomics and data mining coupled to molecular biology and 3D modeling together with technological expertise in production, enzyme stability and immobilization in both batch and continuous reactors for efficient synthesis of novel products.

Contact: Pierre.Monsan @

Physiology and Microbial Metabolism (PM2)

Regroups complimentary approachs including topology and functional regulation of complex metabolic networks, metabolic fl ux analysis and mechanistic modeling based upon enzyme activity and quantitative metabolite analysis, together with molecular approaches to gene regulation. Increasingly involved in whole cell transcriptomics, the axe also has an important specialty in metabolic engineering.

Contact: Jean-Marie.Francois @

Microbial Systems and Bioprocesses (SMB)

Analysis and understanding of the dynamic behaviour of microbial populations within bioreactors with a controlled environment, based upon the integrated use of fermentation technology, microbial physiology and process engineering. Systemic analysis of microbial behaviour in reproducible and fully characterized fermentation conditions taking into account industrial constraints to develop innovative bioprocesses.

Contact: Jean-Louis.Uribelarrea @

Separation-Oxidation-Hybrid Processes (SOPHY)

Downstream engineering expertise coupled to reactor engineering in a multidisciplinary approach integrating physico-chemical concepts to complex biological fluids and environmental analysis to develop knowledge of separation and reaction engineering. Identification of limiting phenomena in complex liquids enabling their treatment and revalorization in innovative hybrid processes.

Contact: Corinne.Cabassud @

Transfer-Interfaces-Mixing (TIM)

Experimental analysis and mathematical modeling of hydrodynamic, mechanical and physico-chemical phenomena involved in multi-phasic and reactive process environments. Fluid mechanics and chemical engineering principles to determine the key diffusional phenomena characteristic of transfer characteristics in fluids containing dispersed inclusions. Detailed studies of specific phenomena identified in pilot studies are used in model systems and then extrapolated to achieve knowledge of the functional behaviour of complex reactions at the process level

Contact: Philippe.Schmitz @