ICEOEngineering and Screening for Original Enzymes (ICEO part of the Toulouse Genopole)

  • Combinatorial engineering enables to modify or improve existing enzyme properties in order to adapt the catalysts to special conditions of use (for industrial applications for example).
  • Generation of large libraries of mutant genes using random or (semi) rational mutagenesis and in vitro recombination, is followed by high-throughput screening of desirable properties using rapid robotized assays.
  • The facility is also used to screen genomic and metagenomic libraries to mine natural enzyme diversity.