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Jean Marie FrançoisProfesseur LISBP

Jean Marie François
Professeur 1st Class
Microbial Physiology and Functional genomics of yeasts and filamentous fungi–PHYGE-
+33 (0) 5 61 55 9492
INSA de Toulouse
135 avenue de Rangueil
31077 Toulouse cedex 4 - FRANCE




  •  1983, Engineer in Agronomy and Biological Chemistry , Catholic University Louvain (Belgium)
  • 1988, Ph D in Biochemistry and Agronomy, Catholic University Louvain (Belgium)
  • 1988-1991, Postdoctoral trainings at North Carolina State University (Prof Dr K. Tatchell), Bordeaux University II (Prof M. Aigle)
  • 1991 -1992, Associate professor at University Catholic of Louvain and Invited lecturer at University Sao-Paulo, Brazil (Department of Biological Chemistry)
  • Since 1993, Professor of Biochemistry, Microbial Physiology and BioNanotechnology at Institut National des Sciences Appliquées and University of Toulouse.



The main activity of the ‘PHYGE” team (see more details at http://biopuce.insa-toulouse.fr/jmflab) deals with a systems approach of metabolic, genetic and genomic adaptation of fungal cells (yeast and filamentous fungi) to environmental conditions that mimic industrial constraints, with emphasis on carbon and energy metabolism, cell wall biogenesis and assembly, and genomic instability. I have also recently initiated an important research project in Synthetic biology aiming at reconstructing new biological pathways capable to generate chemicals or synthons from agroressources. Applications are in white biotechnology (bioethanol, biorefinery, flavours, probiotic/feed additives), agro-nutrition and pharmaceutical industries. My research has been and is currently supported by grants from Europe commission (EU FP4, 5, 6 & 7), national agencies (CNRS, INRA, ANR), regional agencies (Region Midi-Pyrénées) and several industrial companies in the Agro-bioetch fields.
I am also co-responsible of a Bionanobiotechnology network in Toulouse that develops interdisciplinary researches on Biopatterning and integrated Biodetection. This activity is interdisciplinary with Bioengineers, physicists and chemists (to date, 5 seniors’ scientists, 5 Ph D students, and 2 technical Engineers) and its projects are hosted at the new Institute for Advanced Technologies of Life Sciences at the Toulouse Canceropole. Applications are mainly in molecular diagnostic and nanomedicine. Several patents have been already obtained and one spin-off (Dendris, of which I am cofounder) has been emerged from these researches.




  • Teaching Microbial Physiology and functional genomics at INSA
  • Teaching of Molecular Biology and Nanobiotechnology at Physical and Mathematical Engineers
  • Teaching Biology and Bioengineering at Bio-process Engineers at Ecoles des Mines Albi –Carmaux
  • Teaching Biochips technology at Master professional in Molecular Diagnostic, University Toulouse,
  • Invited lecturer at Institute Polytechnic Mexico from 2001 - 2004 : DNA arrays technology and application for functional microbial genomics,
  • Invited lecturer at University of Qingdao, (China) 2001 - 2005 : Lecture in Microbial Physiology and Bioengineering technologies
  • Invited lecturer at University de Ho Chi Minh (Vietnam) 2004: lecture on DNA arrays technology and application for functional genomics,
  • Invited lecturer at University de Biotecnologia y Oenologia, Tarragona, (Spain) 2006: DNA arrays technology and application for functional microbial genomics,
  • Invited lecturer at New Sofia University (Bulgaria) (Erasmus school) (2009 -2010): Lecture on Genomics and post-genomics in Microbiology




Author of > de 120 peer-review papers in Scientific Journal (IFmean ~4,5), 3 text books, 7 patents
Major contributions since 2000
1. François, J. and Parrou, J.L (2001). Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev. 25, 125 - 145.
2. Lagorce, A., Hauser, N., Labourdette, D., Rodriguez, C., Martin-Yken, H., Arroyo, J., Hoheisel, J. and François, J. (2003) Genome wide analysis in response to cell wall mutations of Saccharomyces cerevisiae. J Biol Chem 278, 20345 - 20357
3. Torija, M-J., Lemassu, A., Wilson, W., Roach, P.J., François, J. and Parrou, J.L. (2005). Glycogen synthesis in the absence of glycogenin in the yeast Saccharomyces cerevisiae. FEBS Lett., 579, 3999 - 4004.
4. Martin-Yken, H., Dagkessamanskaia, A., Basmaji, F., Lagorce, A.,and François, J. (2003). The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae. Mol. Microbiol. 49, 23 -35.
5. Kuranda, K., Leberre, V., Sokol, S., Palamarczyk, G. and François, J. (2006). Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways. Mol. Microbiol. 61 (5), 1147 - 1166.
6. Jules, M., Beltran, G., François, J. and Parrou, JL. (2008). New insight in yeast trehalose metabolism. NTH2 encodes a functional cytosolic trehalase and deletion of TPS1 reveals a Ath1p-dependent trehalose mobilisation. Appl. Env. Microbiol. 74, 605 -614.
7. Walther, T., Novo, MA., Rossger, K., Letisse, F. M., Loret, Portais, JC and François, J (2010). Implication of the purine salvage pathway in the ATP homeostasis upon sudden transition from respiratory to fermentative growth conditions. Mol. Syst. Biol. 6: 344 -356.
8. Teste M.A., Francois J M. and Parrou J.L. (2010) Characterization of a new multigenes family encoding isomaltases in the yeast Saccharomyces cerevisiae: the IMA family. J. Biol Chem. 285, 26815 -26824.