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Régis FAURÉ

 

 

Régis FAURÉ

CNRS research scientist

Catalysis and Molecular Enzymatic Engineering Team

+33 (0) 561 559 410

LISBP / INSA de Toulouse

135 avenue de Rangueil

31077 Toulouse cedex 4 - FRANCE

regis.faure@insa-toulouse.fr

 

CV

CNRS research scientist (Enzyme Catalysis, Bioorganic Chemistry & Biomolecular Engineering), LISBP Toulouse, France (2007-present)

Accreditation to supervise research (HDR), UPS Toulouse (2017)

Visiting scientist with Prof. A. Planas, IQS Barcelona, Spain (2015)

Postdoctoral fellow, LISBP Toulouse, France (2006-2007)

Postdoctoral fellow, Prof. R. Roy, Department of Chemistry, UQAM, Canada (2005-2006)

PhD in Biological Chemistry (supervisors: Dr. H. Driguez and Prof. S. Cottaz, CERMAV), UJF Grenoble Grenoble, France (2004)

MSc in Biological Chemistry, UPS, Toulouse, France (2000)

BSc in Physical Chemistry, UPS Toulouse, France (1998)

 

 

Research Topics

Since joining the CNRS in LISBP, I have continued to develop my skills in organic synthesis, while acquiring knowledge and practical skills in the fields of protein biochemistry, enzyme engineering and high-throughput screening. I supply vital in-house expertise in the field of glycochemistry, supporting research focused on enzyme discovery with the design of ad hoc substrates for easy specific detection of enzymatic activities and strong input in the area of enzymatic glycosynthesis using carbohydrate active enzymes. Recently, I began a shift in my research focus towards the redesign of enzyme active sites, based on the use of unnatural amino acids.

 

 

Selected Publications

A single point mutation alters the transglycosylation/hydrolysis partition, significantly enhancing the synthetic capability of an endo-glycoceramidase. (2016) J. Durand, X. Biarnés, L. Watterlot, C. Bonzom, V. Borsenberger, A. Planas, S. Bozonnet, M.J. O’Donohue, R. Fauré* ACS Catal. 6(12):8264-8275. DOI: 10.1021/acscatal.6b02159

 

Molecular design of non-Leloir furanose-transferring enzymes from an α-L-arabinofuranosidase: a rationale for the engineering of evolved transglycosylases (2015) B. Bissaro, J. Durand, X. Biarnés, A. Planas, P. Monsan, M.J. O'Donohue* and R. Fauré* ACS Catal. 5(8):4598-4611. DOI: 10.1021/acscatal.5b00949

 

Glycosynthesis in a Waterworld: new insight into the molecular basis of transglycosylation in retaining glycoside hydrolases (2015) B. Bissaro, P. Monsan, R. Fauré* and M.J. O'Donohue* Biochem. J. 467(1):17-35. DOI: 10.1042/BJ20141412

 

A 1H-NMR study of the specificity of α-L-arabinofuranosidases on natural and unnatural substrates (2014) V. Borsenberger, E. Dornez, M.-L. Desrousseaux, S. Massou, M. Tenkanen, C.M. Courtin, C. Dumon, M.J. O'Donohue and R. Fauré* BBA - Gen. Subjects 1840(10):3106-3114. DOI:10.1016/j.bbagen.2014.07.001

 

En route to a carbohydrate-based vaccine against Burkholderia cepacia (2007) R. Fauré, T.C. Shiao, D. Lagnoux, D. Giguère and R. Roy Org. Biomol. Chem. 5(16):2704-2708. DOI: 10.1039/B708365C

 

Synthesis of a library of xylogluco-oligosaccharides for active-site mapping of xyloglucan endo-transglycosylase (2006) R. Fauré, M. Saura-Valls, H. Brumer III, A. Planas, S. Cottaz and H. Driguez J. Org. Chem. 71(14):5151-5161. DOI: 10.1021/jo0525682

 

To see all my publications, please check my ResearchGate profile (http://www.researchgate.net/profile/Regis_Faure).