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CNRS senior scientist

Enzyme-based Catalysis team

+33 (0) 561 559 410

LISBP / INSA de Toulouse

135 avenue de Rangueil

31077 Toulouse cedex 4 - FRANCE

regis.faure @ insa-toulouse.fr



CNRS research scientist (Enzyme Catalysis, Bioorganic Chemistry & Biomolecular Engineering), LISBP Toulouse, France (2007-present)

Biomolecular engineering: design and molecular study of bio-inspired evolved and/or artificial enzymatic catalysts

Accreditation to supervise research (HDR), UPS Toulouse (2017)

Visiting scientist with A. Planas, IQS Barcelona, Spain (2015)

Postdoctoral fellow with M. O'Donohue, LISBP Toulouse, France (2006-2007)

Postdoctoral fellow with R. Roy, Department of Chemistry, UQAM, Canada (2005-2006)

PhD in Biological Chemistry with H. Driguez & S. Cottaz  (CERMAV), UJF Grenoble, France (2004)

MSc in Biological Chemistry, UPS, Toulouse, France (2000)

BSc in Physical Chemistry, UPS Toulouse, France (1998)



Research Topics

Since joining the CNRS in LISBP, I have continued to develop my skills in organic synthesis, while acquiring knowledge and practical skills in the fields of protein biochemistry, enzyme engineering and high-throughput screening. I supply vital in-house expertise in the field of (glyco)chemistry, supporting research focused on enzyme discovery with the design of ad hoc substrates for easy specific detection of enzymatic activities and strong input in the area of enzymatic glycosynthesis using carbohydrate active enzymes (glycoside hydrolases, esterases, etc.). New enzymatic activities related to the de novo synthesis of carbohydrates are also considered. I have recently also shifted my research towards the redesign of enzyme active sites, based on the use of non-canonical amino acids.



Selected Publications

A single point mutation alters the transglycosylation/hydrolysis partition, significantly enhancing the synthetic capability of an endo-glycoceramidase. (2016) J. Durand, X. Biarnés, L. Watterlot, C. Bonzom, V. Borsenberger, A. Planas, S. Bozonnet, M.J. O’Donohue, R. Fauré* ACS Catal. 6(12):8264-8275. DOI: 10.1021/acscatal.6b02159


Molecular design of non-Leloir furanose-transferring enzymes from an α-L-arabinofuranosidase: a rationale for the engineering of evolved transglycosylases (2015) B. Bissaro, J. Durand, X. Biarnés, A. Planas, P. Monsan, M.J. O'Donohue* and R. Fauré* ACS Catal. 5(8):4598-4611. DOI: 10.1021/acscatal.5b00949


Glycosynthesis in a Waterworld: new insight into the molecular basis of transglycosylation in retaining glycoside hydrolases (2015) B. Bissaro, P. Monsan, R. Fauré* and M.J. O'Donohue* Biochem. J. 467(1):17-35. DOI: 10.1042/BJ20141412


A 1H-NMR study of the specificity of α-L-arabinofuranosidases on natural and unnatural substrates (2014) V. Borsenberger, E. Dornez, M.-L. Desrousseaux, S. Massou, M. Tenkanen, C.M. Courtin, C. Dumon, M.J. O'Donohue and R. Fauré* BBA - Gen. Subjects 1840(10):3106-3114. DOI:10.1016/j.bbagen.2014.07.001


En route to a carbohydrate-based vaccine against Burkholderia cepacia (2007) R. Fauré, T.C. Shiao, D. Lagnoux, D. Giguère and R. Roy Org. Biomol. Chem. 5(16):2704-2708. DOI: 10.1039/B708365C


Synthesis of a library of xylogluco-oligosaccharides for active-site mapping of xyloglucan endo-transglycosylase (2006) R. Fauré, M. Saura-Valls, H. Brumer III, A. Planas, S. Cottaz and H. Driguez J. Org. Chem. 71(14):5151-5161. DOI: 10.1021/jo0525682


To see all my publications, please check my ResearchGate profile http://www.researchgate.net/profile/Regis_Faure