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Articles EAD5


  • Schiavone, M., Castex, M., Siekowzki, N., Dague, E & François, J. (2015). Atomic force microscopy allows revealing effects of autolysis processes and differences in nanomechanical properties of industrial yeast strains FEMS Yeast Res., 15, (2) 1-9
  • Ran L., Formosa, C., Dagkessamanskaia, A., Dague, E. François, J & Martin-Yken, H. (2015). Combining Atomic Force Micsroscopy and genetics to investigate the role of Knr4 in Saccharomyces cerevisiae sensitivity to K9 killer toxin.Nanoletters, (accepted)
  • Julien, S., Tondl, P., Durand,F., Dagkessamanskaia,A., van Tilbeurgh, H., Francois,J, Mourey, L., Zerbib, D., Yken-Martin, H. and Maveyraud, L. (2015) Crystallization and preliminary crystallographic studies of the structured core domain of Knr4 from Saccharomyces cerevisiae, Acta Cryst F, F71.
  • François, J.M (2015) Cell wall interference with transport in yeast. In “Yeast Membrane Transport” (J. Ramos; H. Sychrova & M. Kschisko editors), Springer Verlag, In press
  • Hassan, H., Goma, G & François J. (2015). The influence of carbon/nitrogen ratio on red pigment and citrinin production by filamentous fungi Monascus ruber is dependent on the cultivation mode. Int. Journal Food Science & Technology. DOI: 10.1111/ijfs.12803
  • LLanos A, François JM, Parrou JL (2015). Tracking the best reference genes for RT-qPCR data normalisation in filamentous fungi. BMC genomics, 16: 71
  • Liu, J., Martin-Yken, H., Bigey, F., Dequin, S., Francois, J. & Capp, JP (2015) Natural yeast promoter variants exhibit different noise levels conferring distinct selective advantages. Genome Biol Evol., 7 (4) 969 -984.
  • Grondin, E., Cheong Sing, A.S., Caro, Y., Raheminadimbny, M., Randrianierenana, A., James, S., Nueno-Palop, C., François J. & Petit, T (2015). A comparative study on the potential of epiphytic yeasts isolated from tropical fruits to produce flavoring compounds. Int J Food Microbiol., 203, 101 -108.
  • Petitjean, M., Teste, MA., François, J & Parrou JL (2015). Yeast tolerance to stress relies on Tps1 protein, not on trehalose. J.Biol.Chem., 290, 16177 -16190.
  • Alkim, C., Cam, Y., Trichez, D., Auriol, C., Vax, A., Spina, L., Bartolo, F., Besse, P., François, J & Walther, T (2015). Optimisation of ethylene glycol production from (D) xylose via a synthetic pathway implemented in Escherichia coli. Microb. Cell Fact. 14 :127 DOI 10.1186/s12934-015-0312-7


  • Deng, X., Petitjean, M., Teste, M.A., Trannier, S., François J. & Parrou JL (2014) Similarities and differences in the biochemical and enzymological properties of the four isomaltases from the yeast Saccharomyces cerevisiae. FEBS Open Bio 4, 200-212
  • Pillet, F., Lemonier, S., Schiavone, M., Formosa, C., Martin-Yken, H., François, J & Dague, E (2014). Uncovering by Atomic Force Microscopy of an original circular structure at the yeast cell surface in response to heat shockBMC Biology, 12:6
  • Coutable, A., Thibault, C., Noireaux, V., Vieu, C., Trevisiol, E. & François J M (2014) Cell-free expression and incorporation of the membrane protein a-hemolysin in enriched complex bacterial lipids. BioNanoSci. (in press)
  • Coutable, A., Thibault, C., Chalmeau, J., François, J., Vieu, C, Noireaux, V & Trevisiol, E (2014) Preparation of tethered-lipid bilayers on gold surfaces for the incorporation of integral membrane proteins synthesized by cell free expression. Langmuir  dx.doi.org/10.1021/Ia5004758
  • Walther T., Peyriga L., Alkim C., Liu Y., Agrawal U., Bechter, B., Guo, S., Lardenois, A., Loret, M.O., Martin-Yken, H., Letisse, F., Primig, M. and François J.M (2014) .Cell cycle associated metabolic regulation during meiotic development in yeast. BMC Biology 12: 60
  • Francois, J., Formosa, C., Pillet, F., Schiavone, M., Martin-Yken, M; & Dague, E (2014). Use of Atomic Force Microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae Curr Genet, 59: 187 -196.
  • Schiavone, M., Formosa, C., Martin-Yken, M., Dague, E & François (2014) Combined chemical and enzymatic digestion for a quantitative analysis of the cell wall components in yeasts. FEMS Yeast Res. 14: 933 -947.
  • Formosa, C., lachaize, V., Galès, C., MP Roles, Martin-Yken, H., François, JM., Duval, RE & Dague, E (2014) Mapping HA-taggeed protein at the surface of living cells by Atomic force microscopy. J. Mol. Recognit., 28 : 1-9.
  • Grondin, E., Cheong Sing, A.S., Caro, Y., DeBillerbeck, G., François, J & Petit, T (2014). Physiological and biochemical characteristics of ethyl-tiglate production pathway in the yeast Geotrichum fragrans. Yeast, DOI: 10.1002/yea.3057
  • Vidal, E., Morais, MA, François, J. & deBillerbeck, G (2014) Biosynthesis of higher alcohol flavour compounds by the yeast Saccharomyces cerevisiae: Impact of oxygen availability and responses to glucose pulse in minimal growth medium with leucine as sole nitrogen source. Yeast, DOI: 10.10002/yea.3045
  • Poueymiro, M., Caalé, AC, François, J., Parrou JL., Peeters, N & Genin, S (2014) A Ralstonia solnacearum type III effector directs the production of the plant metabolites trehalose-6-phosphate. mBio, 5 (6) e062065-14
  • Cam, Y., Alkim, C., Trichez, D., Vax, A., Bartolo, F., Besse, Ph., François J & Walther, T (2015) Engineering of a synthetic metabolic pathway for the assimilation of (D)-xylose into added-value chemical. ACS Synthetic Biology, DOI10.1021.acssynbio.5b00103


  • Zhang, H., Fauré, R., François, J., Blanc, PJ & De Billerbeck, G. (2013) Xylosylation as an effective means for reducing yeast growth inhibition by 2-phenylethanol. J Basic Microbiol 53, 1 -4
  • Vidal Espinosa E., De Billerbeck, G., Ardaillon Simoes, D., Schuler, A., François, J & Morias M.A. (2013) Influence of nitrogen supply on the production of higher alcohol/esters and expression of the flavor - related genes in cachaça like-industrial fermentation. Food Chemistry, 138: 701 -708.
  • Alkim, C., Benbadis, L., Cakar, Z.P. & François, J. (2013) Mechanisms other than activation of iron regulon account for the hyper resistance to cobalt of a yeast strain obtained by evolutionary engineering. Metallomics 5 (8), 1043 - 1060
  • Formosa, C., Schiavone, M., Martin-Yken, H., Duval, R.E., François, JM. & Dague, E. (2013). Nanoscale effects of caspofungin on Saccharomyces cerevisiae and Candida albicans.Ant. Agents Chemoth. 57 (8) 3498 -3406.
  • Walther, T., Mtimet, N., Alkim, C., Vax, A., Loret, M-A., Ullah, AZ., Gancedo, G., Smits, G.J & François J (2013) Metabolic phenotypes of Saccharomyces cerevisiae mutants with altered trehalose-6-phosphate dynamics. Biochem.J. 454: 227-237
  • Rezki, M.A, Benbadis, L., Bendayer, Z., de Billerbeck, G., & François J. (2013) Identification and physiologiocal characterization of indigenous yeasts from Algerian food and dairy products. J.Yeast and Fungal Res. 4: 75 -83.
  • De la Mare Marion, Guais, O., Bonnin, E., Weber, J. & Francois J (2013) Molecular and biochemical characterization of three GH62 a-L-arabinofuranosidases from the soil deuteromycete Penicillium funiculosum. Enz. Microbiol Technol. 51 : 351-358
  • Francois, J., Formosa, C., Pillet, F., Schiavone, M., Martin-Yken, M; & Dague, E (2013).Use of Atomic Force Microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae Curr Genet DOI 10.1007/s00294-0113
  • Coutable, A., Noireaux, V., Lepioufle, B., Français, O., Vieu C., François, J., Thibault, C & Trevisiol, E (2013) Insertion of Functional Proteins into Bilayer Lipid Membrane using a Cell-Free Expression System. Biophys. J. 104, 578A
  • Foncy, J., Cau, JC, François, JM., Trevisiol, E.& Severac, C (2013). Comparaison of polyurethane and epoxy resist master molds for nanoscale soft lithography.Microelectronic Engineering, 110: 183 -187
  • Fredonnet J., Foncy, J., Cau, J-C., Trévisiol., E., Peyrade J.P., François, JM. & Séverac, C. (2013) Dynamic PDMS inking for DNA patterning by soft lithography.Microelectronic Engineering, 110: 379 -383
  • Muszkieta, L., Beauvais, A., Pahtz, V., Gibbons, J.G., Anton-Leberre, V., Beau, R., Shibuya, K., Rokas, A., François, JM., Kniemeyer, O., Brakhage, A. & Latge, JP (2013). Investigation of Aspergillus fumigatus biofilm formation by various omics approaches. Frontiers in Microbiology, doi 10.339/micb.2013.00013
  • Hmaïed, F., Helel,S., V. Le berre, V., François J.M., Leclercq,A., M. Lecuit,M.,, H. Smaoui,H., A. Kechrid, A. & Boudabous, A. and Barkallah.I. (2013) Prevalence, identification by a DNA microarray-based assay of human and food isolates Listeria spp. from Tunisia. Patho. Biol. (in press))


  • Yang, D-D., François, JM & De Billerbeck, G (2012) Cloning and characterization of cDNA encoding an aryl-alcohol dehydrogenase from the white-rot fungus Phanerochate chrysosporium. BMC Microbiology (in press)
  • SchlechtU., St.Onge R.P., WaltherT., FrançoisJ. and DavisRW (2012) Cationic amphiphilic drugs are potent inhibitors of yeast sporulation. PLos One, 7, e42853
  • Walther, T., Baylac, A., Alkim, C., Vax, A., Cordier, H. & François J (2012) The PGM3 gens encodes the major phosphoribomutase in the yeast Saccharomyces cerevisiae. FEBS Lett., 5864114 -4118
  • Egea, A., Foncy, J., Cau JC., Paveau V., François, J & Vieu C. (2012) Optical Label-Free Biodetection Based on the Diffraction of DNA Molecular Gratings for In Vitro Diagnostic. Biophys. J., 102, 727A
  • Hassan H., François, JM & Blanc, P.J. (2012) Effect of amino acids on red pigments and citrinin production in Monascus ruber. J. Food Sci., 77, 156 -159.



  • Bechet-Baily, M., Borgs, C., Brauntsein,A. Chayes, J., Dagkessamanskaia, A., François, JM., and Zecchina, R. (2011) Finding undetected protein associations in cell signaling by belief propagation. Proc Natl Acad Sci USA 108 (2):882-88
  • Joubert A., Simoneau P., Campion C., Bataillé-Simoneau N., Iacomi-VasilescuB., Poupard P., François J.M., Georgeault S., Sellier E., Guillemette T (2011). Impact of the unfolded protein response on the pathogenicity of the necrotrophic fungus Alternaria brassicicola.Mol Microbiol., 79, 1305 -1324.
  • Mendes, F., Gonzalez-Pajuelo, M., Cordier, H., François, J & Vasconcelos, I (2011) 1,3 propanediol production in a two-step process fermentation from renewable feedstock. Appl Microbiol Biotechnol. 92, 519 -527.
  • Vidal Espinosa E., De Billerbeck, G., Ardaillon Simoes, D., Schuler, A., François, J & Morias M.A. (2011) Influence of nitrogen supplementation on fermentation kinetics and flavours production during industrial sugar cane juice fermentation for cachaça production. J Food Microbiology (in revision)
  • Hassan H., François, JM & Blanc, P.J. (2011) Effect of amino acids on red pigments and citrinin production in Monascus ruber. J. Food Sci., 77, 156 -159.



  • Walther, T., Novo, MA., Rossger, K., Letisse, F. M., Loret, Portais, JC and François, J (2010). Implication of the purine salvage pathway in the ATP homeostasis upon sudden transition from respiratory to fermentative growth conditions. Mol. Syst. Biol. 6: 344 -356.
  • Guais, O., Tourrasse O., Dourdoigne, M., Parrou J.L. and François J. (2010). Characterization of family GH54-a-L- arabinofuranosidases, including a novel protein bearing a cellulose binding domain in P. funiculosum. Applied Microbiol Biotechnol. 87, 1007 -1021.
  • Dagkessamanskaia, A. Durand, F., Uversky, V.U., BindaM., LopezF., El AzzouziK., Francois, JM and Martin-YkenH. (2010). Functional dissection of an intrinsically disordered protein: Understanding the role of different domains of Knr4 protein in protein-protein interactions. Proteins Sci. 19, 1375 -1383.
  • Teste M.A., Francois J M. and Parrou J.L. (2010) Characterization of a new multigenes family encoding isomaltases in the yeast Saccharomyces cerevisiae: the IMA family. J. Biol Chem. 285, 26815 -26824.
  • Dague, E., Bitar, R., Ranchon, H., Durand, F., Martin-Yken, H., François, J.M (2010) An Atomic Force Microscopy analysis of yeast mutants defective in cell wall architecture. Yeast, 8, 673-684.
  • Dagkessamanskaia,A., El AzzouziK., Kikuchi, Y., Timmers, T., Ohya, Y., Francois,JM and Martin-YkenH (2010) Knr4 N-terminal domain controls its localization and function during sexual differentiation and vegetative growth. Yeast, 8, 563-574.


  • Guais O., Pichereau C., Borderies G., Maestracci, M., Rossignol M. and François J. (2008) Proteomics analysis of a secreted proteins cocktail produced by Penicillium funiculosum under industrial process fermentation. J. Ind. Microbiol. Biotechnol. 35: 1659 -1668.
  • Kuranda, K., Grabinska,K., Berges, T., Le Berre, V., Sokol, S., François, J & Palamarczyk, G(2009). The YTA7 gene is involved in theregulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae.FEMS Yeast Res. 9: 381 - 390.
  • Petek Cakar, Z., Alkim, C., Turanli, B.,Tokman, N., Akman, Süleyman, Sarikaya, M., Tamerler, C. Benbadis, L. andFrançois, J. (2009). Isolation of cobalt hyper-resistant mutants of Saccharomyces cerevisiae by in vivo evolutionary engineering. J. Biotechnol 143, 130-138
  • Kitanovic, A., Walther, T.,Loret, M.O., Holzwarth, J., Kitanovic, I., Bonowski, F., Van Ngoc, B.,Francois, J. and and Wölfl, S. (2009) Metabolic response to MMS-mediated DNAdamage in S.cerevisiae is dependenton glucose concentration in the medium. FEMS Yeast Res. DOI:10.1111/j.1567-1364.2009.00505.x
  • Benbadis, L., Cot, M.,Rigoulet, M. and François, J (2009). Isolation of twocell populations from yeast during high-level alcoholic fermentation thatresemble quiescent and non quiescent cells from stationary phase on glucose. FEMS Yeast Res. Epub ahead of print . PMID 19686340.
  • He, S., Bystricky, K., Leon, S., François, J., Parrou, J. (2009) The Saccharomyces cerevisiae vacuolaracid trehalase is targeted at the cell surface for its physiological function. FEBS J 276, 5432-5446
  • Walther, T., Novo, M., Rossger, K., Benbadis, L.,Letisse, F.,  Loret, MA., Portais, JC andFrançois, J (2009). Implication of the purine salvagepathway in the ATP homeostasis upon sudden transition from respiratory tofermentative growth conditions. Mol. Syst. Biol. (in revision).
  • Teste M.A., Duquenne M.,Francois J. and Parrou J.L. (2009). Validation ofreference genes for quantitative expression analysis by real time-PCR in theyeast Saccharomyces cerevisiae. BMCMol Biol .



  • Jules, M., Beltran, G., François, J. and Parrou,JL. (2008). New insight in yeast trehalose metabolism. NTH2encodes a functional cytosolic trehalase and deletion of TPS1 reveals aAth1p-dependent trehalose mobilisation. Appl. Env. Microbiol. 74, 605 -614.
  • Ansel, J., Bottin, H., Rodriguez-Beltran,C., Damon, C., Nagajaran, M., Ferhmann, S., François, J. and Yvert, G. (2008)Cell to cell stochastic variation in gene expression is a complex genetictrait. PLos Genetics, 4,e1000049
  • Guimarães, P.M., Parrou, J.L., François, J., Teixeira,J.A. and Domingues L. (2008). Adaptive evolution of a lactose - consuming Saccharomycescerevisiae recombinant. Appl.Env. Microbiol. 74, 1748 -1756.
  • Durand F.,Dagkessamanskaia A., Martin-Yken H., Graille, M., Van Tilbeurgh, H., Uversky,V.N. and François J. (2008). Structure-functionanalysis of Knr4/Smi1, a protein indispensable in the absence of a functionalPkc1-Slt2 pathway. Yeast, 25, 563 -576.
  • Guais O., Pichereau C., Borderies G.,Maestracci, M., Rossignol M. and François J. (2008) Proteomics analysis of asecreted proteins cocktail produced by Penicillium funiculosum underindustrial process fermentation. J. Ind. Microbiol. Biotechnol. 35: 1659 -1668.



  • Cot,M., Loret, M-O, François, J. and Benbadis, L. (2007). Physiological behaviourof Saccharomyces cerevisiae in aerated fed-batch process for very highproduction of bioethanol. FEMS Yeast Res. 7, 22 - 32.
  • Cordiez, H., Mendes-Soares, F., Vasconcelos,I. and François, J. (2007) Metabolic and genomic investigation of engineered Saccharomycescerevisiae strains for high glycerol production. Metab. Eng. 9, 364 -378.
  • Frison, M., Parrou, JL., Guillamot, D.,Masquelier, D., François, J., Chaumont, F. and Batoko, H. (2007). The Arabidopsis thaliana Ath1 is a plasma membrane-bound enzyme withextracellular activity. FEBSLett., 581, 4010 -4016.



  • Basmaji, F., Martin-Yken, H. Durand, F.,Dakgessamanskaia, A., Pichereau, C., Rossignol, M. and François, J. (2006). The ‘interactome’ of Knr4/Smi1, a protein implicated in thecoordination of cell wall assembly and cell growth in the yeast Saccharomycescerevisiae. Mol Genet.Genomics, 275, 217-230.
  • Kuranda, K., Leberre,V., Sokol, S., Palamarczyk, G. and François, J. (2006). Investigating thecaffeine effects in the yeast Saccharomyces cerevisiae brings newinsights into the connection between TOR, PKC and Ras/cAMP signalling pathways.Mol. Microbiol. 61(5), 1147 - 1166.
  • Loret, M.O., Pedersen, L., and François, J.(2006). Revised procedures for yeast metabolites extraction. Application to aglucose pulse to carbon-limited yeast cultures, which revealed a transientactivation of the purine salvage pathway. Yeast, 24, 47 -60.
  • François J. (2006). A simple method forquantitative determination of polysaccharides in fungal cell walls. NatureProtocols, 6, (1) 2995 – 3000.



  • Parrou, JL., Jules, M., Beltran, G. andFrançois, J. (2005). Acid trehalases in yeast and fungi: Localisation,regulation and physiological function. FEMS Yeast Res. 5, 503 - 511.
  • Jules, M., Parrou, J.L.and François, J. (2005). Autonomous oscillations in Saccharomycescerevisiae during batch cultures on trehalose. FEBS Journal. 272,1490 - 1500.
  • Torija, M-J., Lemassu, A., Wilson, W., Roach, P.J., François, J. andParrou, J.L. (2005). Glycogen synthesis in the absence of glycogenin in theyeast Saccharomyces cerevisiae. FEBS Lett .579, 3999 - 4004.