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Articles EAD5


Capp, J.-P., Bataille, R. (2018). Multiple myeloma exemplifies a model of cancer based on tissue disruption as the initiator event. Frontiers in Oncology, 8, 12 p. , DOI : 10.3389/fonc.2018.00355 http://prodinra.inra.fr/record/444652 IF=4,4

Yang, D., De Billerbeck, G., Zhang, J.-j., Rosenzweig, F., François, J. m. (2018). Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae. Applied and Environmental Microbiology, 84 (1), e01553-17. , DOI : 10.1128/AEM.01553-17 Web of science® Times Cited : 1 http://prodinra.inra.fr/record/416234 IF=3,6

Walther, T., Calvayrac, F., Malbert, Y., Alkim, C., Dressaire, C., Cordier, H., François, J. m. (2018). Construction of a synthetic metabolic pathway for the production of 2,4-dihydroxybutyric acid from homoserine. Metabolic Engineering. , DOI : 10.1016/j.ymben.2017.12.005 http://prodinra.inra.fr/record/416233 IF=7,8

Formosa-Dague, C., Castelain, M., Martin-Yken, H., Dunker, K., Dague, E., Sletmoen, M. (Auteur de correspondance) (2018). The role of glycans in bacterial adhesion to mucosal surfaces: how can single-molecule techniques advance our understanding?. Microorganisms, 6 (2), 26 p. , DOI : 10.3390/microorganisms6020039 http://prodinra.inra.fr/record/443664 IF=new journal

Martin-Yken, H., Gironde, C., Derick, Darius, H. T., Furger, Laurent, D., Chinain (2018). Ciguatoxins activate the Calcineurin signalling pathway in Yeasts: Potential for development of an alternative detection tool?. Environmental Research, 162, 144-151. , DOI : 10.1016/j.envres.2017.12.022 http://prodinra.inra.fr/record/417250 IF=4,7

Irague, R., Topham, C., Martineau, N., Baylac, A., Auriol, C., Walther, T., François, J.-M., Andre, I. (Auteur de correspondance), Remaud Simeon, M. (Auteur de correspondance) (2018). A generic HTS assay for kinase screening: Validation for the isolation of an engineered malate kinase. Plos One, 13 (2), 15 p. , DOI : 10.1371/journal.pone.0193036 http://prodinra.inra.fr/record/424398 IF=2,8

Trichez, D., Auriol, C., Baylac, A., Irague, R., Dressaire, C., Carnicer Heras, M., Heux, S., François, J. m. (Auteur de correspondance), Walther, T. (2018). Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid. Microbial Cell Factories, 17 (1), 12 p. , DOI : 10.1186/s12934-018-0959-y http://prodinra.inra.fr/record/438562 IF=3,8

Chuppa-Tostain, G., Hoarau, J., Watson, M., Adelard, L., Cheong Sing, A., Caro, Y., Grondin, I., Bourven, I., Francois, J., Girbal-Neuhauser, E. & Petit T. (2018) Production of Aspergillus niger biomass on sugracan distillery wastemwater: physiological aspects and potential for biodiesel production. Fungal Biol. Biotechnol., 5: 1 doi.org/10.1186/s40694-018-0045-6 IF= not indexed yet

Lopez, R.V., Gomez, J.L., Spina, L., Dejean, S., Parrou, JL & François, J M. (2018). Trehalose-6-phosphate promotes fermentation and glucose repression in Saccharomyces cerevisiae. Microbial Cell 5, 444-459. DOI: 10.15698/mic2018.10.651 IF= not indexed yet

Deshors, M., Guais, O., Neugnot-Roux, V., Cameleyre, X., Fillaudeau, L., Francois, J.M. (2018). Enzymatic deconstruction mechanism of complex polysaccharides in wheat revealed by combined in situ physical and ex-situ biochemical studies. Front. Bioeng Biotechnol. (accepted) IF=4,23

Frazao C.R, Maton, V., Walther, T. & François, J.M (2018) Development of a metabolite sensor for high-throughput detection of aldehydes in Escherichia coli. Front. Bioeng Biotechnol, section Synth. Biol., 6: 118, DOI: 10.3389/fbioe.2018.00118 IF=4.36


Frazao C.R., Topham, C., Malbert, Y., Walther, T., François, J.M. (2018). Rational engineering of a malate dehydrogenase for microbial production of 2,4 dihydroxybutyric acid production via homoserine pathway. Biochem. J. DOI: 10.1042/BCJ20180765 IF=3.8

Senescau, A., Kempowsky, T., Bernard, E., Messier, S., Besse, Ph., Fabre, R. & François, J. M. (2018) Innovative DendrisChips® technology for a syndromic approach of in vitro diagnosis: Application to the Respiratory infectious diseases. Diagnostics MDPI, 8: 77 , doi: 10.3390/diagnostics8040077. IF=2,43

Liu J, Lestrade D, Cescut J, François JM, Capp JP (2018). A GRX1 promoter variant confers constitutive noisy bimodal expression that increases oxidative stress resistance in yeast, Front Microbiol., 9:2158. doi: 10.3389/fmicb.2018.02158 IF=4,0

Liu J, Arabaciyan S, François JM, Capp JP (2018). Bimodality of gene expression from yeast promoter can be instigated by DNA context, inducing conditions and strain background. FEMS Yeast Res. Jun 1;18(4). doi: 10.1093/femsyr/foy047 IF=2,6 

Labas, V., Teixeira-Gomes, A. P., Bouguereau, L., Gargaros, A., SPINA, L., Marestaing, A., Uzbekova, S. (2018). Intact cell MALDI-TOF mass spectrometry on single bovine oocyte and follicular cells combined with top-down proteomics: A novel approach to characterise markers of oocyte maturation. Journal of Proteomics, 175, 56-74. , DOI : 10.1016/j.jprot.2017.03.027 http://prodinra.inra.fr/record/390544 IF=3.7

Francois, J.-M., Alkim, C., Lachaux, C., Walther, T. (2018). Engineering carbon-conserving synthetic pathways for assimilation and conversion of C5/C6 carbon sources into added value chemicals. New Biotechnology, 44. , DOI : 10.1016/j.nbt.2018.05.074 . IF 3,74  http://prodinra.inra.fr/record/449051

Llanos, A., Dejean, S., Neugnot-Roux, V., François, J.M. & Parrou, JL (2018)Carbon sources and XlnR—dependent Transcriptional landscape of CAZymes in the industrial fungus Talaromyces versatilis: when exception seems to be the rule. Microbial Cell Fact.doi.org/10.1186/s12934-019-1062-8. IF 4.17



Grondin, E., Shum Cheong Sing, A., Caroa, Y., James, S., Nueno-Palop,C., François, JM.& Petit, T (2017) Flavour production by Saprochaete and Geotrichum yeasts and their close relatives. Food Chem. 237: 677-684.**


Turanlı-Yıldız, B., Benbadis, L., Alkım, C., Sezgin, T.,  Aksit, A., Gökçe, A., Öztürk,Y., Tarık Baykal, A., Çakar, Z.P. andFrançois J M (2017) In vivo evolutionary engineering for ethanol-tolerance of Saccharomyces cerevisiae haploid cells triggers diploidization. J Biosci. Bioeng. https://doi.org/10.1016/j.jbiosc.2017.04.012


Walther Th., Topham, C.M., Irague, R., Auriol, C., Baylac, A., Cordier, H., Dressaire, C., Lozano-Huguet, L., Tarrat, N., Martineau, N., Stodel, M., Malbert, Y., Maestracci, M., Huet, R., André, I., Remaud-Siméon, M & François J M. (2017) Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid. Nature Comm., 8, 15828 doi:10.1038/ncomms15828.


Schiavone, M., Déjean, S., Sieczkowski, N., Castex, M., Dague, E. and François J M (2017) Integration of biochemical, biophysical and transcriptomics data for investigating the structural and nanomechanical properties of the yeast cell wall. Frontiers in Microbiology, 8: 1809; DOI: 10.3389/fmicb.2017.01806 **


Yang, DD., De Billerberck, G., Zhang J-J , Rosenzweig, F. & François, J M. (2017) Deciphering the origin, evolutionary fate and the physiological function of the subtelomeric multi-aryl-alcohol dehydrogenases encoded genes family in the yeast Saccharomyces cerevisiae. Applied Env. Microbiol DOI.org/ 10.1128/AEM.01553.17 ***


Capp JP. (2017)  Tissue disruption increases stochastic gene expression thus producing tumors: cancer initiation without driver mutation.

Int J Cancer. 2017 Jun 1;140(11):2408-2413. doi: 10.1002/ijc.30596. Epub 2017 Jan 17. Review.


Petitjean M, Teste MA, Leger-Silvestre I,  François JM, Parrou JL.  A new function for the yeast trehalose-6P synthase (Tps1) protein, as key pro-survival factor during growth, chronological ageing, and apoptotic stress.  Mechanisms of Ageing and Development. January 2017 161: 234–246.  doi: 10.1016/j.mad.2016.07.011 


Teissié, J. and D. Zerbib (2017). Eradication of Bacteria Via Electropulsation " in Reference Module in Chemistry, Molecular Sciences and Chemical Engineering." Elsevier Inc. Editor-in-Chief, Jan Reedijk Sciencedirect. DOI: 10.1016/B978-0-12-409547-2.13455-9      Review dans book


Teissié, J. and D. Zerbib (2017). Cell Membrane Electropermeabilization" in Reference Module in Chemistry, Molecular Sciences and Chemical Engineering." Elsevier Inc.  Editor-in-Chief, Jan Reedijk Sciencedirect. DOI: 10.1016/B978-0-12-409547-2.14139-3            Review dans Book


Majoral, J.P., Senescau, A., Fabre, R. & François, JM (2017) DNA-Based Multiplexing Technology for Rapid and Accurate Diagnosis of Pathogens. An Original Contribution of Phosphorus Dendrimers. In”Phosphorous Dendrimers in Biology and Nanomedicine: Syntheses, Characterization, and Properties, chapter 14, Edited by AM Caminade, C-O Turrin & JP Majoral, Pan Stanford Publishing Pte Ltd


Anthony Silvano, Jose-Maria Heras, Julie Mekoue-Nguela, Marion Schiavone, Nathalie Sieczkowski (2017) Développement d’un nouvel autolysat de levure spécifique innovant pour l’amélioration de la qualité des vins rouges. Revue des oenologues N°164.



Schiavone, M., Elsztein, C., Formosa-Dague, C., Teste, M-A., Martin-Yken, H., Morais, M.A.jr, Dague, E. & François, J. (2016).An Atomic Force Microscopy study of the response of the yeast Saccharomyces cerevisiae to ethanol stress. Appl.Env Microbiol., 82: 4789-4801 Dept genetic, University Pernambuco, Recife, Brasil


Petitjean, M., Teste, MA., Leger-Silvestre, I. François, J & Parrou, JL (2017). A new function for the yeast trehalose-6-P synthase (Tps1) protein, as key prosurvival factor during growth, chronological ageing and apoptotic stress. Mech Ageing Dev. 2017 Jan;161(Pt B):234-246. doi: 10.1016/j.mad.2016.07.011. Epub 2016 Aug 6.


Grondin, E., Shum Cheong Sing, A., Caroa, Y., James, S., Nueno-Palop,C., François, JM.& Thomas Petit, T (2017) Flavour production by Saprochaete and Geotrichum yeasts and their close relatives. Food Chem. 2017 Dec 15;237:677-684. doi: 10.1016/j.foodchem.2017.06.009. Epub 2017 Jun 3.


Alkim, C., Trichez, D., Cam, Y., François, J & Walther, T (2016). The synthetic xylulose 1-phosphate pathway increases production of glycolic acid from xylos-rich sugar mictures. BMC Biotechnol. Biofuels, 9:201


Fredonnet, J., Foncy, J., Severac, C., François, J & Trevisiol, E (2016) Innovative automation device employing soft lithography for the production of low density DNA microarrays. Microarrays 2016, 5, 25; doi:10.3390/microarrays5040025


François, J.M (2016) Cell Surface Interference with Plasma Membrane and Transport Processes in Yeasts in Advances in Experimental Medicine and Biology, Volume 892 pp 11-31, doi: 10.1007/978-3-319-25304-6_2. Springer Verlag


Liu, J., François, J & Capp, JC (2016) Use of gene expression as experimental parameters to test phenotypic effects. Yeast, 33: 209-2016


Walther, Th & François, J (2016)Microbial production of propanol. Biotechnol Adv., 34: 984-996


Martin-Yken, H., François, J. & Zerbib, D (2016) Knr4: a disordered hub protein at the heart of fungal cell wall signalling. Cellular Microbiology,


Ceren Alkim, Debora Trichez, Yvan Cam, Lucie Spina, Jean Marie François, Thomas Walther (2016) The synthetic xylulose-1 phosphate pathway increases production of glycolic acid from xylose-rich sugar mixtures. Biotechnology for Biofuels, 2016, Volume 9, Number 1, Page 1


Cam Y, Alkim C, Trichez D, Trebosc V, Vax A, Bartolo F, Besse P, François JM1, Walther T (2016) Engineering of a Synthetic Metabolic Pathway for the Assimilation of (d)-Xylose into Value-Added Chemicals. ACS Synth Biol. 2016 Jul 15;5(7):607-18. doi: 10.1021/acssynbio.5b00103. Epub 2015 Jul 24.




Vidal, E., Morais, MA, François, J. & deBillerbeck, G (2015) Biosynthesis of higher alcohol flavour compounds by the yeast Saccharomyces cerevisiae: Impact of oxygen availability and responses to glucose pulse in minimal growth medium with leucine as sole nitrogen source. Yeast, DOI: 10.10002/yea.3045


Formosa, C., lachaize, V., Galès, C., MP Roles, Martin-Yken, H., François, JM., Duval, RE & Dague, E (2015) Mapping HA-taggeed protein at the surface of living cells by Atomic force microscopy. J. Mol. Recognit., 28 : 1-9.


Hassan, H., Goma, G & François J. (2015). The influence of carbon/nitrogen ratio on red pigment and citrinin production by filamentous fungi Monascus ruber is dependent on the cultivation mode. Int. Journal Food Science & Technology. DOI: 10.1111/ijfs.12803


LLanos A, François JM, Parrou JL (2015). Tracking the best reference genes for RT-qPCR data normalisation in filamentous fungi. BMC genomics, 16: 71


Schiavone, M., Castex, M., Siekowzki, N., Dague, E & François, J. (2015). Atomic force microscopy allows revealing effects of autolysis processes and differences in nanomechanical properties of industrial yeast strains FEMS Yeast Res., 15, (2) 1-9,


Liu, J., Martin-Yken, H., Bigey, F., Dequin, S., Francois, J. & Capp, JP (2015) Natural yeast promoter variants exhibit different noise levels conferring distinct selective advantages. Genome Biol Evol., 7 (4) 969 -984.


Petitjean, M., Teste, MA., François, J & Parrou JL (2015). Yeast tolerance to stress relies on Tps1 protein, not on trehalose. J.Biol.Chem., 290, 16177 -16190.


Grondin, E., Cheong Sing, A.S., Caro, Y., Raheminadimbny, M., Randrianierenana, A., James, S., Nueno-Palop, C., François J. & Petit, T (2015). A comparative study on the potential of epiphytic yeasts isolated from tropicla fruits to produce flavoring compounds. Int J Food Microbiol., 203, 101 -108.


Djordjević R, Gibson B, Sandell M, de Billerbeck GM, Bugarski B, Leskošek-Čukalović I, Vunduk J, Nikićević N, Nedović V. (2015) Raspberry wine fermentation with suspended and immobilized yeast cells of two strains of Saccharomyces cerevisiae. Yeast, 32:271-279. doi: 10.1002/yea.3060.


Carlquist M1, Gibson B, Karagul Yuceer Y, Paraskevopoulou A, Sandell M, Angelov AI, Gotcheva V, Angelov AD, Etschmann M, de Billerbeck GM, Lidén G (2015). Process engineering for bioflavour production with metabolically active yeasts - a mini-review. Yeast, 32(1):123-143. doi: 10.1002/yea.3058.


Morrissey JP, Etschmann MM, Schrader J, de Billerbeck GM (2015) Cell factory applications of the yeast Kluyveromyces marxianus for the biotechnological production of natural flavour and fragrance molecules.Yeast. 32: 3-16. doi: 10.1002/yea.3054.


Ran L., Formosa, C., Dagkessamanskaia, A., Dague, E. François, J & Martin-Yken, H. (2015). Combining Atomic Force Microscopy and genetics to investigate the role of Knr4 in Saccharomyces cerevisiae sensitivity to K9 killer toxin. Nanoletters, (accepted)


Cam, Y., Alkim, C., Trichez, D., Vax, A., Bartolo, F., Besse, Ph., François J & Walther, T (2015) Engineering of a synthetic metabolic pathway for the assimilation of (D)-xylose into added-value chemical. ACS Synthetic Biology, DOI10.1021.acssynbio.5b00103


Julien S, Tondl P, Durand F, Dagkessamanskaia A, van Tilbeurgh H, Francois J, Mourey L, Zerbib D, Yken-Martin H. and Maveyraud  L. (2015) Crystallization and preliminary crystallographic studies of the structured core domain of Knr4 from Saccharomyces cerevisiae, Acta Cryst F, F71.


Ene I.V, Walker LA, Schiavone M, Lee KK, Martin-Yken H, Dague E, Gow NA, Munro CA, Brown AJ (2015) Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance MBio. 6(4):e00986. doi: 10.1128/mBio.00986-15


Formosa C., Pillet F., Schiavone M., Duval R.E., Ressier L., Dague E., 2015. Generation of living cell arrays for Atomic Force Microscopy studies Nature Protocols 10. 1. 199-204.


Alkim, C., Cam, Y., Trichez, D., Auriol, C., Vax, A., Spina, L., Bartolo, F., Besse, P., François, J & Walther, T (2015). Optimisation of ethylene glycol production from (D) xylose via a synthetic pathway implemented in Escherichia coli. Microb. Cell Fact. 14 :127 DOI 10.1186/s12934-015-0312-7


Ceroni, F., Haynes, K.A.,; Carbonell, P and François, J.M eds.(2015) Synthetic biology engineering ccomplexity and refactoring cell capabilities. Lausanne: Frontiers Media doi:10.3389/978-2-88919-685-2


François, J.M (2015) Cell wall interference with transport in yeast. In “Yeast Membrane Transport” (J. Ramos; H. Sychrova & M. Kschisko editors), Springer Verlag




  • Deng, X., Petitjean, M., Teste, M.A., Trannier, S., François J. & Parrou JL (2014) Similarities and differences in the biochemical and enzymological properties of the four isomaltases from the yeast Saccharomyces cerevisiae. FEBS Open Bio 4, 200-212
  • Pillet, F., Lemonier, S., Schiavone, M., Formosa, C., Martin-Yken, H., François, J & Dague, E (2014). Uncovering by Atomic Force Microscopy of an original circular structure at the yeast cell surface in response to heat shockBMC Biology, 12:6
  • Coutable, A., Thibault, C., Noireaux, V., Vieu, C., Trevisiol, E. & François J M (2014) Cell-free expression and incorporation of the membrane protein a-hemolysin in enriched complex bacterial lipids. BioNanoSci. (in press)
  • Coutable, A., Thibault, C., Chalmeau, J., François, J., Vieu, C, Noireaux, V & Trevisiol, E (2014) Preparation of tethered-lipid bilayers on gold surfaces for the incorporation of integral membrane proteins synthesized by cell free expression. Langmuir  dx.doi.org/10.1021/Ia5004758
  • Walther T., Peyriga L., Alkim C., Liu Y., Agrawal U., Bechter, B., Guo, S., Lardenois, A., Loret, M.O., Martin-Yken, H., Letisse, F., Primig, M. and François J.M (2014) .Cell cycle associated metabolic regulation during meiotic development in yeast. BMC Biology 12: 60
  • Francois, J., Formosa, C., Pillet, F., Schiavone, M., Martin-Yken, M; & Dague, E (2014). Use of Atomic Force Microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae Curr Genet, 59: 187 -196.
  • Schiavone, M., Formosa, C., Martin-Yken, M., Dague, E & François (2014) Combined chemical and enzymatic digestion for a quantitative analysis of the cell wall components in yeasts. FEMS Yeast Res. 14: 933 -947.
  • Formosa, C., lachaize, V., Galès, C., MP Roles, Martin-Yken, H., François, JM., Duval, RE & Dague, E (2014) Mapping HA-taggeed protein at the surface of living cells by Atomic force microscopy. J. Mol. Recognit., 28 : 1-9.
  • Grondin, E., Cheong Sing, A.S., Caro, Y., DeBillerbeck, G., François, J & Petit, T (2014). Physiological and biochemical characteristics of ethyl-tiglate production pathway in the yeast Geotrichum fragrans. Yeast, DOI: 10.1002/yea.3057
  • Vidal, E., Morais, MA, François, J. & deBillerbeck, G (2014) Biosynthesis of higher alcohol flavour compounds by the yeast Saccharomyces cerevisiae: Impact of oxygen availability and responses to glucose pulse in minimal growth medium with leucine as sole nitrogen source. Yeast, DOI: 10.10002/yea.3045
  • Poueymiro, M., Caalé, AC, François, J., Parrou JL., Peeters, N & Genin, S (2014) A Ralstonia solnacearum type III effector directs the production of the plant metabolites trehalose-6-phosphate. mBio, 5 (6) e062065-14
  • Cam, Y., Alkim, C., Trichez, D., Vax, A., Bartolo, F., Besse, Ph., François J & Walther, T (2015) Engineering of a synthetic metabolic pathway for the assimilation of (D)-xylose into added-value chemical. ACS Synthetic Biology, DOI10.1021.acssynbio.5b00103



  • Zhang, H., Fauré, R., François, J., Blanc, PJ & De Billerbeck, G. (2013) Xylosylation as an effective means for reducing yeast growth inhibition by 2-phenylethanol. J Basic Microbiol 53, 1 -4
  • Vidal Espinosa E., De Billerbeck, G., Ardaillon Simoes, D., Schuler, A., François, J & Morias M.A. (2013) Influence of nitrogen supply on the production of higher alcohol/esters and expression of the flavor - related genes in cachaça like-industrial fermentation. Food Chemistry, 138: 701 -708.
  • Alkim, C., Benbadis, L., Cakar, Z.P. & François, J. (2013) Mechanisms other than activation of iron regulon account for the hyper resistance to cobalt of a yeast strain obtained by evolutionary engineering. Metallomics 5 (8), 1043 - 1060
  • Formosa, C., Schiavone, M., Martin-Yken, H., Duval, R.E., François, JM. & Dague, E. (2013). Nanoscale effects of caspofungin on Saccharomyces cerevisiae and Candida albicans.Ant. Agents Chemoth. 57 (8) 3498 -3406.
  • Walther, T., Mtimet, N., Alkim, C., Vax, A., Loret, M-A., Ullah, AZ., Gancedo, G., Smits, G.J & François J (2013) Metabolic phenotypes of Saccharomyces cerevisiae mutants with altered trehalose-6-phosphate dynamics. Biochem.J. 454: 227-237
  • Rezki, M.A, Benbadis, L., Bendayer, Z., de Billerbeck, G., & François J. (2013) Identification and physiologiocal characterization of indigenous yeasts from Algerian food and dairy products. J.Yeast and Fungal Res. 4: 75 -83.
  • De la Mare Marion, Guais, O., Bonnin, E., Weber, J. & Francois J (2013) Molecular and biochemical characterization of three GH62 a-L-arabinofuranosidases from the soil deuteromycete Penicillium funiculosum. Enz. Microbiol Technol. 51 : 351-358
  • Francois, J., Formosa, C., Pillet, F., Schiavone, M., Martin-Yken, M; & Dague, E (2013).Use of Atomic Force Microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae Curr Genet DOI 10.1007/s00294-0113
  • Coutable, A., Noireaux, V., Lepioufle, B., Français, O., Vieu C., François, J., Thibault, C & Trevisiol, E (2013) Insertion of Functional Proteins into Bilayer Lipid Membrane using a Cell-Free Expression System. Biophys. J. 104, 578A
  • Foncy, J., Cau, JC, François, JM., Trevisiol, E.& Severac, C (2013). Comparaison of polyurethane and epoxy resist master molds for nanoscale soft lithography.Microelectronic Engineering, 110: 183 -187
  • Fredonnet J., Foncy, J., Cau, J-C., Trévisiol., E., Peyrade J.P., François, JM. & Séverac, C. (2013) Dynamic PDMS inking for DNA patterning by soft lithography.Microelectronic Engineering, 110: 379 -383
  • Muszkieta, L., Beauvais, A., Pahtz, V., Gibbons, J.G., Anton-Leberre, V., Beau, R., Shibuya, K., Rokas, A., François, JM., Kniemeyer, O., Brakhage, A. & Latge, JP (2013). Investigation of Aspergillus fumigatus biofilm formation by various omics approaches. Frontiers in Microbiology, doi 10.339/micb.2013.00013
  • Hmaïed, F., Helel,S., V. Le berre, V., François J.M., Leclercq,A., M. Lecuit,M.,, H. Smaoui,H., A. Kechrid, A. & Boudabous, A. and Barkallah.I. (2013) Prevalence, identification by a DNA microarray-based assay of human and food isolates Listeria spp. from Tunisia. Patho. Biol. (in press))



  • Yang, D-D., François, JM & De Billerbeck, G (2012) Cloning and characterization of cDNA encoding an aryl-alcohol dehydrogenase from the white-rot fungus Phanerochate chrysosporium. BMC Microbiology (in press)
  • SchlechtU., St.Onge R.P., WaltherT., FrançoisJ. and DavisRW (2012) Cationic amphiphilic drugs are potent inhibitors of yeast sporulation. PLos One, 7, e42853
  • Walther, T., Baylac, A., Alkim, C., Vax, A., Cordier, H. & François J (2012) The PGM3 gens encodes the major phosphoribomutase in the yeast Saccharomyces cerevisiae. FEBS Lett., 5864114 -4118
  • Egea, A., Foncy, J., Cau JC., Paveau V., François, J & Vieu C. (2012) Optical Label-Free Biodetection Based on the Diffraction of DNA Molecular Gratings for In Vitro Diagnostic. Biophys. J., 102, 727A
  • Hassan H., François, JM & Blanc, P.J. (2012) Effect of amino acids on red pigments and citrinin production in Monascus ruber. J. Food Sci., 77, 156 -159.



  • Bechet-Baily, M., Borgs, C., Brauntsein,A. Chayes, J., Dagkessamanskaia, A., François, JM., and Zecchina, R. (2011) Finding undetected protein associations in cell signaling by belief propagation. Proc Natl Acad Sci USA 108 (2):882-88
  • Joubert A., Simoneau P., Campion C., Bataillé-Simoneau N., Iacomi-VasilescuB., Poupard P., François J.M., Georgeault S., Sellier E., Guillemette T (2011). Impact of the unfolded protein response on the pathogenicity of the necrotrophic fungus Alternaria brassicicola.Mol Microbiol., 79, 1305 -1324.
  • Mendes, F., Gonzalez-Pajuelo, M., Cordier, H., François, J & Vasconcelos, I (2011) 1,3 propanediol production in a two-step process fermentation from renewable feedstock. Appl Microbiol Biotechnol. 92, 519 -527.
  • Vidal Espinosa E., De Billerbeck, G., Ardaillon Simoes, D., Schuler, A., François, J & Morias M.A. (2011) Influence of nitrogen supplementation on fermentation kinetics and flavours production during industrial sugar cane juice fermentation for cachaça production. J Food Microbiology (in revision)
  • Hassan H., François, JM & Blanc, P.J. (2011) Effect of amino acids on red pigments and citrinin production in Monascus ruber. J. Food Sci., 77, 156 -159.



  • Walther, T., Novo, MA., Rossger, K., Letisse, F. M., Loret, Portais, JC and François, J (2010). Implication of the purine salvage pathway in the ATP homeostasis upon sudden transition from respiratory to fermentative growth conditions. Mol. Syst. Biol. 6: 344 -356.
  • Guais, O., Tourrasse O., Dourdoigne, M., Parrou J.L. and François J. (2010). Characterization of family GH54-a-L- arabinofuranosidases, including a novel protein bearing a cellulose binding domain in P. funiculosum. Applied Microbiol Biotechnol. 87, 1007 -1021.
  • Dagkessamanskaia, A. Durand, F., Uversky, V.U., BindaM., LopezF., El AzzouziK., Francois, JM and Martin-YkenH. (2010). Functional dissection of an intrinsically disordered protein: Understanding the role of different domains of Knr4 protein in protein-protein interactions. Proteins Sci. 19, 1375 -1383.
  • Teste M.A., Francois J M. and Parrou J.L. (2010) Characterization of a new multigenes family encoding isomaltases in the yeast Saccharomyces cerevisiae: the IMA family. J. Biol Chem. 285, 26815 -26824.
  • Dague, E., Bitar, R., Ranchon, H., Durand, F., Martin-Yken, H., François, J.M (2010) An Atomic Force Microscopy analysis of yeast mutants defective in cell wall architecture. Yeast, 8, 673-684.
  • Dagkessamanskaia,A., El AzzouziK., Kikuchi, Y., Timmers, T., Ohya, Y., Francois,JM and Martin-YkenH (2010) Knr4 N-terminal domain controls its localization and function during sexual differentiation and vegetative growth. Yeast, 8, 563-574.


  • Guais O., Pichereau C., Borderies G., Maestracci, M., Rossignol M. and François J. (2008) Proteomics analysis of a secreted proteins cocktail produced by Penicillium funiculosum under industrial process fermentation. J. Ind. Microbiol. Biotechnol. 35: 1659 -1668.
  • Kuranda, K., Grabinska,K., Berges, T., Le Berre, V., Sokol, S., François, J & Palamarczyk, G(2009). The YTA7 gene is involved in theregulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae.FEMS Yeast Res. 9: 381 - 390.
  • Petek Cakar, Z., Alkim, C., Turanli, B.,Tokman, N., Akman, Süleyman, Sarikaya, M., Tamerler, C. Benbadis, L. andFrançois, J. (2009). Isolation of cobalt hyper-resistant mutants of Saccharomyces cerevisiae by in vivo evolutionary engineering. J. Biotechnol 143, 130-138
  • Kitanovic, A., Walther, T.,Loret, M.O., Holzwarth, J., Kitanovic, I., Bonowski, F., Van Ngoc, B.,Francois, J. and and Wölfl, S. (2009) Metabolic response to MMS-mediated DNAdamage in S.cerevisiae is dependenton glucose concentration in the medium. FEMS Yeast Res. DOI:10.1111/j.1567-1364.2009.00505.x
  • Benbadis, L., Cot, M.,Rigoulet, M. and François, J (2009). Isolation of twocell populations from yeast during high-level alcoholic fermentation thatresemble quiescent and non quiescent cells from stationary phase on glucose. FEMS Yeast Res. Epub ahead of print . PMID 19686340.
  • He, S., Bystricky, K., Leon, S., François, J., Parrou, J. (2009) The Saccharomyces cerevisiae vacuolaracid trehalase is targeted at the cell surface for its physiological function. FEBS J 276, 5432-5446
  • Walther, T., Novo, M., Rossger, K., Benbadis, L.,Letisse, F.,  Loret, MA., Portais, JC andFrançois, J (2009). Implication of the purine salvagepathway in the ATP homeostasis upon sudden transition from respiratory tofermentative growth conditions. Mol. Syst. Biol. (in revision).
  • Teste M.A., Duquenne M.,Francois J. and Parrou J.L. (2009). Validation ofreference genes for quantitative expression analysis by real time-PCR in theyeast Saccharomyces cerevisiae. BMCMol Biol .



  • Jules, M., Beltran, G., François, J. and Parrou,JL. (2008). New insight in yeast trehalose metabolism. NTH2encodes a functional cytosolic trehalase and deletion of TPS1 reveals aAth1p-dependent trehalose mobilisation. Appl. Env. Microbiol. 74, 605 -614.
  • Ansel, J., Bottin, H., Rodriguez-Beltran,C., Damon, C., Nagajaran, M., Ferhmann, S., François, J. and Yvert, G. (2008)Cell to cell stochastic variation in gene expression is a complex genetictrait. PLos Genetics, 4,e1000049
  • Guimarães, P.M., Parrou, J.L., François, J., Teixeira,J.A. and Domingues L. (2008). Adaptive evolution of a lactose - consuming Saccharomycescerevisiae recombinant. Appl.Env. Microbiol. 74, 1748 -1756.
  • Durand F.,Dagkessamanskaia A., Martin-Yken H., Graille, M., Van Tilbeurgh, H., Uversky,V.N. and François J. (2008). Structure-functionanalysis of Knr4/Smi1, a protein indispensable in the absence of a functionalPkc1-Slt2 pathway. Yeast, 25, 563 -576.
  • Guais O., Pichereau C., Borderies G.,Maestracci, M., Rossignol M. and François J. (2008) Proteomics analysis of asecreted proteins cocktail produced by Penicillium funiculosum underindustrial process fermentation. J. Ind. Microbiol. Biotechnol. 35: 1659 -1668.



  • Cot,M., Loret, M-O, François, J. and Benbadis, L. (2007). Physiological behaviourof Saccharomyces cerevisiae in aerated fed-batch process for very highproduction of bioethanol. FEMS Yeast Res. 7, 22 - 32.
  • Cordiez, H., Mendes-Soares, F., Vasconcelos,I. and François, J. (2007) Metabolic and genomic investigation of engineered Saccharomycescerevisiae strains for high glycerol production. Metab. Eng. 9, 364 -378.
  • Frison, M., Parrou, JL., Guillamot, D.,Masquelier, D., François, J., Chaumont, F. and Batoko, H. (2007). The Arabidopsis thaliana Ath1 is a plasma membrane-bound enzyme withextracellular activity. FEBSLett., 581, 4010 -4016.



  • Basmaji, F., Martin-Yken, H. Durand, F.,Dakgessamanskaia, A., Pichereau, C., Rossignol, M. and François, J. (2006). The ‘interactome’ of Knr4/Smi1, a protein implicated in thecoordination of cell wall assembly and cell growth in the yeast Saccharomycescerevisiae. Mol Genet.Genomics, 275, 217-230.
  • Kuranda, K., Leberre,V., Sokol, S., Palamarczyk, G. and François, J. (2006). Investigating thecaffeine effects in the yeast Saccharomyces cerevisiae brings newinsights into the connection between TOR, PKC and Ras/cAMP signalling pathways.Mol. Microbiol. 61(5), 1147 - 1166.
  • Loret, M.O., Pedersen, L., and François, J.(2006). Revised procedures for yeast metabolites extraction. Application to aglucose pulse to carbon-limited yeast cultures, which revealed a transientactivation of the purine salvage pathway. Yeast, 24, 47 -60.
  • François J. (2006). A simple method forquantitative determination of polysaccharides in fungal cell walls. NatureProtocols, 6, (1) 2995 – 3000.



  • Parrou, JL., Jules, M., Beltran, G. andFrançois, J. (2005). Acid trehalases in yeast and fungi: Localisation,regulation and physiological function. FEMS Yeast Res. 5, 503 - 511.
  • Jules, M., Parrou, J.L.and François, J. (2005). Autonomous oscillations in Saccharomycescerevisiae during batch cultures on trehalose. FEBS Journal. 272,1490 - 1500.
  • Torija, M-J., Lemassu, A., Wilson, W., Roach, P.J., François, J. andParrou, J.L. (2005). Glycogen synthesis in the absence of glycogenin in theyeast Saccharomyces cerevisiae. FEBS Lett .579, 3999 - 4004.