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Production scientifique

2019

Lippens G, Gigant B. Elucidating Tau function and dysfunction in the era of cryo-EM. J Biol Chem. 2019 May 14. pii: jbc.REV119.008031. doi:10.1074/jbc.REV119.008031

 

Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J,Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu  I, Bitan G, Smet-Nocca C. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. ACS Chem Biol. 2019 May 15. doi:10.1021/acschembio.9b00325

 

Palazzolo, A. , Feuillastre, S. , Pfeifer, V. , Garcia‐Argote, S. , Bouzouita, D. , Tricard, S. , Chollet, C. , Marcon, E. , Buisson, D. , Cholet, S. , Fenaille, F. , Lippens, G. , Chaudret, B. and Pieters, G., Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange. Angew. Chem. 2019, 58(15):4891-4895.

 

Integrated pH Measurement during Reaction Monitoring with Dual-Reception 1H–31P NMR Spectroscopy. Cox N, Kuemmerle R, Millard P, Cahoreau E,  François JM, Parrou JL, and Lippens G, Anal Chem 2019, 91(6):3959-3963

 

2018

Lopez JM, Antiparra R, Lippens G, Zimic M, Sheen P, Maruenda H. Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor  of Trypanosoma cruzi. Biomol NMR Assign. 2018, doi:10.1007/s12104-018-9844-1.

Wallin C, Hiruma Y, Wärmländer SKTS, Huvent I, Jarvet J, Abrahams JP, Gräslund A, Lippens G, Luo J. The Neuronal Tau Protein Blocks in Vitro Fibrillation of the  Amyloid-β (Aβ) Peptide at the Oligomeric Stage. J Am Chem Soc. 2018 Jul 5;140(26):8138-8146.

 

Sinnaeve D, Dinclaux M, Cahoreau E, Millard P, Portais JC, Létisse F, Lippens  G. Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J-Resolved NMR Spectroscopy. Anal Chem. 2018, 90(6):4025-4031.

 

Lippens G, Cahoreau E, Millard P, Charlier C, Lopez J, Hanoulle X, Portais JC. In-cell NMR: from metabolites to macromolecules. Analyst. 2018;143(3):620-629.

2017

Dujardin M, Cantrelle FX, Lippens G, Hanoulle X. Interaction study between HCV NS5A-D2 and NS5B using (19)F NMR. J Biomol NMR. 2017, doi: 10.1007/s10858-017-0159-9.

 

Claverie, M., Cioci, G., Vuillemin, M., Monties, N., Roblin, P., Lippens, G., Remaud Simeon, M., Moulis, C. Investigations on the Determinants Responsible for Low Molar Mass Dextran Formation by DSR-M Dextransucrase. ACS Catalysis, 7 (10), 7106-7119.

 

Bessa LM, Launay H, Dujardin M, Cantrelle FX, Lippens G, Landrieu I, Schneider R, Hanoulle X. NMR reveals the intrinsically disordered domain 2 of NS5A protein  as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B. J Biol Chem. 2017;292(44):18024-18043.

 

Despres C, Byrne C, Qi H, Cantrelle FX, Huvent I, Chambraud B, Baulieu EE, Jacquot Y, Landrieu I, Lippens G, Smet-Nocca C. Identification of the Tau phosphorylation pattern that drives its aggregation. Proc Natl Acad Sci U S A. 2017;114(34):9080-9085.

 

Malki I, Cantrelle FX, Sottejeau Y, Lippens G, Lambert JC, Landrieu I. Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain. FEBS J. 2017;284(19):3218-3229.

 

Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle FX, Delolme F, Fogeron ML, Molle J, Montserret R, Bockmann A, Bartenschlager R, Lohmann V, Lippens G, Ricard-Blum S, Hanoulle X, Penin F. Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A. Biochemistry. 2017;56(24):3029-3048.

 

 Martínez-Prieto LM, Baquero EA, Pieters G, Flores JC, de Jesús E, Nayral C, Delpech F, van Leeuwen PWNM, Lippens G, Chaudret B. Monitoring of nanoparticle reactivity in solution: interaction of l-lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange. Chem Commun (Camb. 2017;53(43):5850-5853.

 

Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN. Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nat Commun. 2017;8:14937.

 

Zhao J, Huvent I, Lippens G, Eliezer D, Zhang A, Li Q, Tessier P, Linhardt RJ, Zhang F, Wang C. Glycan Determinants of Heparin-Tau Interaction. Biophys J. 2017;112(5):921-932.

 

Millard P, Cahoreau E, Heuillet M, Portais JC, Lippens G. (15)N-NMR-Based Approach for Amino Acids-Based (13)C-Metabolic Flux Analysis of Metabolism. Anal Chem. 2017, 89(3):2101-2106.

 

Louis E, Cantrelle FX, Mesotten L, Reekmans G, Bervoets L, Vanhove K, Thomeer M, Lippens G, Adriaensens P. Metabolic phenotyping of human plasma by (1) H-NMR at high and medium magnetic field strengths: a case study for lung cancer. Magn Reson Chem. 2017, 55(8):706-713.

 

Qi H, Despres C, Prabakaran S, Cantrelle FX, Chambraud B, Gunawardena J, Lippens G, Smet-Nocca C, Landrieu I. The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein. Methods Mol Biol. 2017;1523:179-213.

 

Gandhi NS, Kukic P, Lippens G, Mancera RL. Molecular Dynamics Simulation of Tau Peptides for the Investigation of Conformational Changes Induced by Specific Phosphorylation Patterns. Methods Mol Biol. 2017;1523:33-59.

 

2016

Danis C, Despres C, Bessa LM, Malki I, Merzougui H, Huvent I, Qi H, Lippens G, Cantrelle FX, Schneider R, Hanoulle X, Smet-Nocca C, Landrieu I. Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins. J Vis Exp. 2016;(118).

 

Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y. A β-Turn Motif in the  Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry. 2016;55(38):5366-76

 

Lippens G, Landrieu I, Smet C, Huvent I, Gandhi NS, Gigant B, Despres C, Qi H, Lopez J. NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules. 2016;6(2).

 

Lopez J, Schneider R, Cantrelle FX, Huvent I, Lippens G. Studying Intrinsically Disordered Proteins under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy. Angew Chem Int Ed Engl. 2016;55(26):7418-22.

 

Kamah A, Cantrelle FX, Huvent I, Giustiniani J, Guillemeau K, Byrne C, Jacquot Y, Landrieu I, Baulieu EE, Smet C, Chambraud B, Lippens G. Isomerization  and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent  Processes. J Mol Biol. 2016;428(6):1080-90.

 

Qi H, Prabakaran S, Cantrelle FX, Chambraud B, Gunawardena J, Lippens G, Landrieu I. Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. J Biol Chem. 2016;291(14):7742-53.

 

Ahuja P, Cantrelle FX, Huvent I, Hanoulle X, Lopez J, Smet C, Wieruszeski JM, Landrieu I, Lippens G. Proline Conformation in a Functional Tau Fragment. J Mol Biol. 2016;428(1):79-91